Comparing cardiac MRI and lung PET/CT after completion of tuberculosis treatment – preliminary findings of participants co-enrolled into the StatinTB trial and Cardiac Imaging After TB (CIA-TB) study

Abstract Introduction Mortality rates after successful tuberculosis (TB) treatment remain elevated and healthy survival is impaired by chronic pulmonary disease persistent inflammation. Inflammation leads to a complex cascade of events has been associated with cardiovascular (CVD). Recent epidemiological work described an increased risk CVD in persons history TB. Aims objectives In our ongoing StatinTB trial (NCT04147286), we evaluate safety efficacy 40 mg atorvastatin reduce lung inflammation (PLI) TB HIV−/HIV+ adults measured 18F-FDG-PET/CT. Participants are co-enrolled into the Cardiac Imaging After Tuberculosis (CIA-TB) study. Here report preliminary findings participants enrolled CIA-TB study aim correlate PLI cardiac magnetic resonance imaging (CMR) parameters. Methods clinical response negative sputum culture at 16 weeks were screened end 24-week course for drug-sensitive PET/CT was performed on Philips Gemini TF scanner analysed using MIM®Software. defined as total glycolysis (TLG) ≥50 SUV·mL (Figure 1). CMR 3T Siemens Magnetom Skyra parameters derived from following acquisitions: SSFP cine short long axes, T1 mapping (MOLLI, 5 (3) 3), T2 late gadolinium enhancement (LGE) imaging. conducted according ICH-GCP. Results 26 (mean age 37.8±13.8 years, 38.5% women) underwent CMR. 23.1% infected HIV, 34.6% smokers, 26.9% had previous Median BMI 21.3 (IQR 19.7; 24.3). One participant reported hypertension. Common symptoms enrollment cough (26.9%), shortness breath (11.5%), chest pain (3.9%). On CT scan, 73.1% nodules, 57.7% scarring, 50.0% cavities, 42.3% bronchiectasis, 19.2% centrilobular disease, distorted architecture, 11.5% consolidations. PET/CT, detected among 11 (42.3%) mean TLG 216.0 78.2; 384.0). multivariable regression analysis, left ventricular systolic volume (LVESV) (−1.46; 95% CI: −2.89, −0.23; p=0.047) architecture (2.84; 1.17, 4.52; p=0.003) significantly TLG. Native relaxation time showed strong, but not significant association (15.01; −8.08, 38.10; p=184). Conclusion We present data young cohort without factors. Structural affecting least half participants, many symptomatic. more than one-third suggest impairment. Further enrolment laboratory studies will shed light post-TB cardio-pulmonary sequelae. Funding Acknowledgement Type funding sources: Public grant(s) – EU funding. Main source(s): EDCTP